منابع مشابه
GEF-effector interactions
Members of the Arf family of small GTP-binding proteins, or GTPases, are activated by guanine nucleotide exchange factors (GEFs) that catalyze GDP release from their substrate Arf, allowing GTP to bind. In the secretory pathway, Arf1 is first activated by GBF1 at the cis-Golgi, then by BIG1 and BIG2 at the trans-Golgi and trans-Golgi network (TGN). Upon activation, Arf1-GTP interacts with effec...
متن کاملTrio’s Rho-specific GEF domain is the missing G q effector in C. elegans
Program in Molecular, Cell, and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA; Institute of Experimental and Clinical Pharmacology, Medical Faculty Mannheim, University of Heidelberg, D-68169 Mannheim, Germany; Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA; Department of Pharmacology,...
متن کاملInteraction between the Type III Effector VopO and GEF-H1 Activates the RhoA-ROCK Pathway
Vibrio parahaemolyticus is an important pathogen that causes food-borne gastroenteritis in humans. The type III secretion system encoded on chromosome 2 (T3SS2) plays a critical role in the enterotoxic activity of V. parahaemolyticus. Previous studies have demonstrated that T3SS2 induces actin stress fibers in various epithelial cell lines during infection. This stress fiber formation is strong...
متن کاملRethinking receptor-G protein-effector interactions.
Hundreds of different receptors regulate the activity of effector proteins with the assistance of heterotrimeric guanine nucleotide-binding proteins (G proteins). The hypothesis that G protein-coupled receptors (R) govern their effectors (E) indirectly via a shuttling mechanism involving the exchange of heterotrimeric G proteins (G[alpha betagamma]) or parts thereof (G[alpha], G[betagamma]) bet...
متن کاملThe Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes
Vacuolar protein sorting 9 (VPS9)-ankyrin-repeat protein (Varp) has recently been identified as an effector molecule for two small GTPases-Rab32 and Rab38-in the transport of a melanogenic enzyme tyrosinase-related protein 1 (Tyrp1) to melanosomes in melanocytes. Although Varp contains a Rab21-guanine nucleotide exchange factor (GEF) domain (i.e., VPS9 domain), since Rab21-GEF activity is not r...
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ژورنال
عنوان ژورنال: Cellular Logistics
سال: 2014
ISSN: 2159-2799
DOI: 10.4161/21592780.2014.943616